There was this one site in a town I used to live in that was like a serial restaurant graveyard. In 10 years at least 5 different restaurants opened there and closed, usually in 1-2 years. It was a cool building but the reason seemed fairly clear to me: it was downtown, in a city with poor public transportation, off the main strip, and had no parking other than a pay garage 2 1/2 blocks away and around the corner. People tried an Italian restaurant, a sports themed dinner place, fine dining, a Chinese restaurant, another Italian restaurant, and a bar and grill.