What immediately bugs you when watching an episode? Mine is when they transport someone sitting down and they reintegrate in a standing position (or vice versa). Sure, the tech is near magical but my suspension of disbelief pretty much snaps when they do this.
The lack of immortality. Sure, you could go the, “We have found that the distinct possibility of death makes life more meaningful” BS, but really - would it take that much power to have someone step into a transporter each night before bed (like taking a very short shower), get buffered, and then sleep? Next day: “Oh no! Lt. Promiscuous has been decapitated! Oh well, beam her back to life and update her on the last 5 hours and we’re good to go again.”
I get it that for plot purposes, that can’t be a thing. But there should be a very good explanation as to why it’s not being done.
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In Strange New Worlds, which is set earlier than Scotty could have invented that, the doctor keeps patients in the pattern buffer when their condition is deteriorating and there’s nothing he can do to stop it. It’s presented as janky and his own invention, and not necessarily harmless.