I also realised that the Shadowrun games (Returns, Dragonfall, and Hong Kong) might scratch that itch - the setting is a cyberpunk/fantasy mashup, and the game play is similar isometric point and click until you get into combat when it becomes isometric turn based tactical. I was recommended to start with Dragonfall
It has a great story, you’re in for a ride!
I also realised that the Shadowrun games (Returns, Dragonfall, and Hong Kong) might scratch that itch - the setting is a cyberpunk/fantasy mashup, and the game play is similar isometric point and click until you get into combat when it becomes isometric turn based tactical. I was recommended to start with Dragonfall