On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
The post says I’m the boss, so as a human I’m going to pick my own home galaxy as the reference. Alien species would have their own coordinate systems but it’s not that hard to convert between them, or to specify which reference you’re using. We’ll already be converting between planetary/system/galactic/intergalactic coordinate systems all the time so it’s not much harder to account for a few more.