On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
Easy, the sun is the bright spot and anything else is too far away to even begin to think about exploring, so the Sun is a good point of reference for early explorers. Once you journey further than our solar system, you’d need another point of reference and it would most likely be the solar system as a whole.