There are plenty of great options: Giggs, Scholes, Baresi, Maldini, Facchetti, Puyol, etc.
For me though, the greatest is Francesco Totti. The others above played for clubs who won multiple trophies, and all won the champions league at least once. Aside from a smattering of Coppa Italias and one Scudetto, Totti didn’t win anything with Rome.
For me, it’s easier for a top player to stay at a top club, rather than be a top player like Totti and stay at a club that was rarely considered the best in Serie A. For my money, he is the greatest one-club man of all time.
Who would you choose?
For me, Sandro Mazzola. Huge legend for Internazionale. 4 Serie A, two European cups, two intercontinental cups, Serie A top scorer, Euro championship with Italy, world cup final 2 years later. and all that with the tragic loss of his father in the Superga air disaster.